Head-to-head
OrderlyMeds vs LillyDirect (Zepbound): GLP-1 Prices Compared
Released: Last reviewed:
On October 15, 2026, OrderlyMeds’s all-in price at the maintenance dose averages $299 a month and LillyDirect (Zepbound)’s $486, so OrderlyMeds costs $187 less a month on average; OrderlyMeds costs $2,249 less over a year of month-to-month billing ($3,588 vs $5,837).
Only prices read on the providers’ own pages on October 15, 2026 produce a verdict here; older records are shown with their dates and are not compared. Confirm the total at checkout.
Tirzepatide: OrderlyMeds vs LillyDirect (Zepbound)
| OrderlyMeds | LillyDirect (Zepbound) | |
|---|---|---|
| All-in monthly at maintenance | $299/mo | $486/mo ($449 per 4 weeks) |
| Cheapest 12-month route, per month | $299/mo | $486/mo |
| 12-month cost | $3,588 | $5,837 |
| Membership / program fee | None | None |
| Dose pricing | Flat across doses (stated) | By dose: $299 (2.5 mg), $399 (5 mg), $449 (7.5-15 mg) when each refill is bought within 45 days; otherwise $499 (7.5 mg) and $699 (10-15 mg) |
| Status | Verified · 2026-10-15 | Verified · 2026-10-15 |
The arithmetic
On October 15, 2026, OrderlyMeds’s all-in price at the maintenance dose averages $299 a month and LillyDirect (Zepbound)’s $486, so OrderlyMeds costs $187 less a month on average; OrderlyMeds costs $2,249 less over a year of month-to-month billing ($3,588 vs $5,837).
Semaglutide: OrderlyMeds vs LillyDirect (Zepbound)
| OrderlyMeds | LillyDirect (Zepbound) | |
|---|---|---|
| All-in monthly at maintenance | $149/mo | Not offered |
| Cheapest 12-month route, per month | $149/mo | Not offered |
| 12-month cost | $1,788 | Not offered |
| Membership / program fee | None | Not offered |
| Dose pricing | Flat across doses (stated) | Not offered |
| Status | Verified · 2026-10-15 | Not offered |
The arithmetic
No like-for-like semaglutide verdict: LillyDirect (Zepbound) does not offer semaglutide.
Terms side by side
OrderlyMeds
- Billing2-month starter paid up front ($299 for 2 months), then the standard monthly rate
- CancellationWhen you sign up, you can cancel any time before the doctor finalizes your prescription, unless you've selected a multi-month plan.
- PharmacyWe currently partner with PerfectRx/PerfectionRx, ProRx, Casa, Pharmacy Hub and SmartPharmaRx. (All our pharmacy partners are 503A designated.)
LillyDirect (Zepbound)
- BillingNo subscription; self-pay per fill; Lilly defines a month as 28 days
- PharmacyLillyDirect self-pay pharmacy channel
Questions people ask
Is OrderlyMeds or LillyDirect (Zepbound) cheaper for tirzepatide?
On October 15, 2026, OrderlyMeds’s all-in price at the maintenance dose averages $299 a month and LillyDirect (Zepbound)’s $486, so OrderlyMeds costs $187 less a month on average; OrderlyMeds costs $2,249 less over a year of month-to-month billing ($3,588 vs $5,837). Both figures are all-in monthly prices at the maintenance dose, including any membership fee.
What does a year of tirzepatide cost at OrderlyMeds and LillyDirect (Zepbound)?
Using each program’s cheapest published 12-month route as read on October 15, 2026: $3,588 at OrderlyMeds and $5,837 at LillyDirect (Zepbound). Prepaid plans lower the monthly price but raise what you lose if you stop early, so read the refund terms first.
Are compounded GLP-1s from either program FDA-approved?
No compounded tirzepatide or semaglutide is FDA-approved, and neither is a generic version of Zepbound, Mounjaro, Wegovy or Ozempic. Brand products sold by LillyDirect and NovoCare are FDA-approved. Ask which pharmacy fills your prescription and check its state license.
What will checkout show that this page does not?
Taxes, state availability, current promotions and any change made after our read date. Screenshot the order summary before you pay; that screen, not a comparison page, shows what you are agreeing to.
Records: OrderlyMeds · LillyDirect (Zepbound) · price database · downloads. Official sites: OrderlyMeds ↗ · LillyDirect (Zepbound) ↗.