Head-to-head · computed 2026-08-11
LifeMD vs ShedRx
LifeMD: LifeMD attaches a $149/month program fee to medication pricing; its compounded tirzepatide all-in figure ($597) is the highest in our index, though its insurance-navigation pathway for brand products is a genuine strength. ShedRx: ShedRx advertises accessible entry pricing ($175 semaglutide, $199 tirzepatide) but tiers upward with dose — $249 and $289 respectively at the maintenance basis.
Tirzepatide
| LifeMD | ShedRx | |
|---|---|---|
| All-in maintenance | $597/mo | $289/mo |
| Best plan rate | $597/mo | $289/mo |
| 12-month total | $7,164 | $3,468 |
| Status | Provider-stated · 2026-08-05 | Provider-stated · 2026-08-05 |
The arithmetic
On the figures our desk holds, ShedRx's $289 a month undercuts LifeMD's $597 by $308 a month at the 10 mg/wk maintenance basis — $3,696 across a year. ShedRx's figure is provider-stated (captured 2026-08-05) and LifeMD's is provider-stated (captured 2026-08-05); a status below 'verified' means our independent checkout capture is still pending, so treat the gap as the best current evidence rather than settled fact.
LifeMD's tirzepatide ladder runs $597 a month billed monthly. ShedRx's runs $289 a month billed monthly. On the twelve-month basis ShedRx's $3,468 beats LifeMD's $7,164 by $3,696 — with the winner's figure resting on twelve months at the month-to-month rate with no commitment, a structural difference that matters if you might stop early.
Semaglutide
| LifeMD | ShedRx | |
|---|---|---|
| All-in maintenance | $348/mo | $249/mo |
| Best plan rate | $348/mo | $249/mo |
| 12-month total | $4,176 | $2,988 |
| Status | Provider-stated · 2026-08-05 | Provider-stated · 2026-08-05 |
The arithmetic
On the figures our desk holds, ShedRx's $249 a month undercuts LifeMD's $348 by $99 a month at the 2.4 mg/wk maintenance basis — $1,188 across a year. ShedRx's figure is provider-stated (captured 2026-08-05) and LifeMD's is provider-stated (captured 2026-08-05); a status below 'verified' means our independent checkout capture is still pending, so treat the gap as the best current evidence rather than settled fact.
LifeMD's semaglutide ladder runs $348 a month billed monthly. ShedRx's runs $249 a month billed monthly. On the twelve-month basis ShedRx's $2,988 beats LifeMD's $4,176 by $1,188 — with the winner's figure resting on twelve months at the month-to-month rate with no commitment, a structural difference that matters if you might stop early.
Where the structures genuinely differ
ShedRx carries no membership fee against LifeMD's $149 a month — $1,788 a year of structural cost before any medication ships, which is why this site prices everything all-in. On dose economics, LifeMD is dose-flat — the price survives titration — while ShedRx's pricing can move with the dose, a difference that compounds through a standard escalation schedule and matters most to buyers expecting to reach the higher maintenance doses. LifeMD works with insurance pathways while ShedRx is cash-pay only — decisive if you hold coverage worth using (the indication doors map when you do), irrelevant if you're paying cash either way.
Structure, side by side
LifeMD
- Membership$149/mo
- Dose policyFlat at published rate
- CommitmentMonth-to-month
- CancellationCancel anytime
- PharmacyPartner pharmacies
ShedRx
- MembershipNone
- Dose policyTiered by dose
- CommitmentMonth-to-month
- CancellationCancel before renewal
- PharmacyPartner pharmacies
What our desk is watching on each
LifeMD: Highest all-in compounded tirzepatide in the index; the value case rests on clinical service and insurance help, not price.
ShedRx: Start-vs-maintenance spread is among the widest in the index; budget on the maintenance figure.
Questions people ask
Is LifeMD or ShedRx cheaper in 2026?
The tirzepatide and semaglutide verdict blocks above give the computed answer at the maintenance basis, with the verification status of each figure; the short version is that whichever program's all-in monthly number is lower on this page is cheaper on the evidence we hold today, and both rows carry capture dates so you can judge freshness.
What does LifeMD vs ShedRx miss that checkout will show?
Taxes, state availability, current promotions, and any dose surcharge introduced after our capture date. Screenshot the order summary before paying — that capture, not any comparison page, is your contract.
Why do you compare at the maintenance dose instead of the starting dose?
Because starter pricing lasts one or two months and maintenance pricing lasts the rest of the year; comparing starts against maintenances is the single most common way GLP-1 comparisons mislead.
What do LifeMD and ShedRx cost over a full year of tirzepatide?
On the plans our database holds, a year of tirzepatide runs $7,164 at LifeMD and $3,468 at ShedRx — computed from each program's best published twelve-month route, with promotional figures labeled in the sections above and every number carrying its capture date.
Both records live in the normalized database; re-run the math yourself from the downloads. Full record pages: LifeMD · ShedRx. Official sites: LifeMD ↗ · ShedRx ↗. Nothing here is medical advice.